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pentobarbital decreases amounts of toremifene by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe. CYP3A4 inducers maximize charge of toremifene metabolism, lowering the constant-state focus in serum.pentobarbital will lessen the level or outcome of ripretinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism.pentob